Immunology Research

Immunology Research Laboratories

Cell Signalling Laboratory

The focus of research in the Cell Signalling Laboratory is to understand what turns a benign cancer cell, which remains, local and treatable to a metastatic cell capable of spreading to multiple organs.


Name A/Prof Yeesim Khew-Goodall
Telephone +61 8 830 27741
Email yeesim.khew-goodall@unisa.edu.au
Website Centre for Cancer Biology: Cell Signalling Laboratory

 

Centre for Clinical and Experimental Transplantation

The Centre for Clinical and Experimental Transplantation is a research centre that brings together a wide variety of expertise relating to transplantation, cellular therapies, kidney disease and immunobiology.


Name A/Prof Toby Coates
Telephone +61 8 822 20957
Email toby.coates@sa.gov.au
Website Centre for Clinical and Experimental Transplantation

 

Cytokine Receptor Laboratory

The laboratory seeks to understand the mechanism of cytokine receptor activation, in particular the GM-CSF, IL-3 and IL-5 receptors, in health and disease, contributing to the development of new drugs for unmet clinical needs such as leukaemia, asthma and arthritis.


Name Prof Angel Lopez
Telephone +61 8 830 27915
Email angel.lopez@health.sa.gov.au
Website Centre for Cancer Biology: Cytokine Receptor Laboratory

 

Detmold Family Trust Cell Imaging Centre

The Detmold Family Trust Cell Imaging Centre provides staff and students of SA Pathology, and other research institutions, access to state-of-the-art cell sorters, flow cytometers and microscopes, with specialist staff on hand to assist investigators in achieving the best results from their studies.

The Detmold Family Trust Cell Imaging Centre was so named to acknowledge the Detmold family’s generous donation towards the purchase of the flow cytometer. The gift commemorates Mr Phillip Detmold, who died of leukaemia in 2001. These funds were met by an equal contribution from the Department of Human Services.

Funding for the original confocal microscope came predominantly from the Welcome Trust and was due to the tireless efforts of a small group of researchers at the Hanson Institute. The Facility provides specialist cell-imaging which enhances the research activities being undertaken across the campus.


Name Kate Pilkington
Telephone +61 8 830 27469
Email katherine.pilkington@unisa.edu.au
Website www.adelaidecytometry.com

 

Gene Regulation Laboratory

Professor Greg Goodall

We have discovered that the miR-200 family of microRNAs controls epithelial to mesenchymal transition (EMT), which is considered to be a key step in cancer metastasis, which is the major cause of death from cancer. We have found that these microRNAs have to be turned off to allow cancer cells to become invasive and that if we enforce expression of the microRNAs, we can block the EMT process and even convert the migratory cells back to non-migratory, ‘epithelial’ cells. In ongoing work we are examining the mechanisms that control production and loss of the microRNAs; identifying the gene targets of the microRNAs; examining human tumours for involvement of the microRNAs in invasion and metastasis and using in vitro and in vivo models to identify the pathways through which they operate. We are also using next generation sequencing and bioinformatics to understand cancer pathways controlled by microRNAs.


Name Prof Greg Goodall
Telephone +61 8 830 27751
Email Gregory.Goodall@unisa.edu.au
Website Centre for Cancer Biology: Gene Regulation Laboratory

 

Molecular Signalling Laboratory

The Molecular Signalling Laboratory examines cell signalling pathways that contribute to cancer and other diseases. In particular, the primary focus of our work is on the sphingolipid pathway, which can trigger increased cell survival, increased cell proliferation, and new blood vessel formation; three of the classic hallmarks of cancer. Indeed, we and others have established that sphingosine kinase, a central enzyme in the sphingolipid pathway, plays an important role in many different cancers, and is an attractive target for anti-cancer therapy. Our studies are directed in 3 main areas: (i) to understand the molecular mechanisms regulating sphingosine kinase in cancer, (ii) developing agents that target sphingosine kinase, or its regulation, as anti-cancer agents, and (iii) defining the downstream pathways important for sphingolipid-mediated cancer cell signalling.


Name Prof Stuart Pitson
Telephone +61 8 830 27832
Email stuart.pitson@unisa.edu.au
Website Centre for Cancer Biology: Molecular Signalling Laboratory

 

Vascular Biology and Cell Trafficking Laboratory

Dr Claudine Bonder is a Heart Foundation Fellow and Head of the Vascular Biology and Cell Trafficking Laboratory at the Centre for Cancer Biology in Adelaide, South Australia.

From her research training during her PhD at Flinders University and post-doctoral position at the University of Calgary (Canada) she has gained expert experience in vascular and cellular biology, immunology, inflammation and imaging.

The focus of Dr Bonder’s laboratory is the blood vasculature and how it contributes to health and disease. More specifically, she and her team investigate (i) endothelial progenitor cells, (ii) leukocyte trafficking and (iii) activation of the vasculature during diseases such as heart disease, breast cancer, melanoma and allergy. Dr Bonder’s research has culminated in important advances in this area, including (i) identifying the adhesion molecules used by leukocyte subsets and progenitor cells to traffic to inflamed organs, (ii) defining mediators of endothelial progenitor cell function and differentiation and (iii) identifying key surface expressed receptors which regulate major cell survival signals.


Name A/Prof Claudine Bonder
Telephone +61 8 830 27833
Email claudine.bonder@unisa.edu.au
Website Centre for Cancer Biology: Vascular Biology Laboratory