Bone and Joint Research

Centre for Orthopaedic and Trauma Research Bone Cell Biology Laboratory

Adelaide Centre for Spinal Research

The centre studies the biomechanics of the musculoskeletal and nervous systems in normal, diseased and injured states. The laboratory has close collaboration between research and clinics.


Name Prof Brian Freeman
Telephone +61 8 831 37472
Email brian.freeman@adelaide.edu.au
Website none

 

Orthopaedic and Trauma Research

The core focus of the Centre for Orthopaedic and Trauma Research Bone Cell Biology Laboratory is to elucidate the pathobiology of the bone related diseases osteoarthritis, osteoporosis, rheumatoid arthritis and bone cancer.


Name Prof. David Findlay
Telephone +61 8 822 25621
Email david.findlay@adelaide.edu.au
Website none
Name A/Prof Gerald Atkins
Telephone +61 8 822 23107
Email gerald.atkins@adelaide.edu.au
Website none

 

Endocrine Bone Laboratory

Studies in our laboratory have focussed on characterising dietary and hormonal factors influencing bone structure and strength particularly as related to osteoporosis. In particular, we are interested on the contribution of vitamin D status to bone structure and cellular proliferation and maturation.

We have consequently developed rodent models of vitamin D depletion to study changes to bone structure and bone cell activity. We have also developed and obtained a number of knock-out and transgenic mouse models to study the roles of direct vitamin D activity and metabolism within the skeleton. These models have been used successfully and been the subject of numerous publications and NHMRC project grants.

Collaborations with clinicians have allowed the laboratory to participate in clinical studies to develop and test hypothesises arising from the animal model work. This work has integrated biochemical, hormonal, and dietary interactions with quantification of skeletal structure, strength and bone cell activities including molecular signalling.


Name Prof Howard Morris
Telephone +61 8 822 23031
Email howard.morris@health.sa.gov.au
Website none

 

Musculoskeletal Biology Research Laboratory

The Musculoskeletal Biology Research Laboratory (MBRL) explores fundamental bone biology research with an emphasis on preventative strategies to minimise bone loss associated with osteoporosis. Current treatment therapies are poor partly because administration can only be given later in life, for relatively short periods and usually only when significant bone loss has already occurred. New strategies to prevent bone loss in the first place are urgently needed.

Vitamin D deficiency is an issue which keeps popping up in the media, as it is suggested that many more of us are vitamin D deficient than ever before. From a clinical perspective, we investigate the issues of what levels of vitamin D do we need to prevent a multitude of diseases, including osteoporosis. We are also describing in detail what the molecular and cellular effects of changes to vitamin D activity within the skeleton on overall bone health. These studies are demonstrating the role of vitamin D in is determining bone health and define how much vitamin D is needed for skeletal health.


Name A/Prof Paul Anderson
Telephone +61 8 822 23244
Email paul.anderson@unisa.edu.au
Website none